Media Capacity Expansion & Multi-Product Plant Conversion

Confidential BioPharm Manufacturer

This specialty biopharmaceutical manufacturer entrusted Hart with a combined $12 m scope of mechanical and general construction work on their media expansion and multi-product plant conversion projects.

The media capacity expansion required Hart to provided process equipment to the existing production line, including product temperature control modules and (2) production media vessels up to 9000 liters. Installation demanded the extension of plant utilities and hygienic systems to new equipment under full plant production operations, with critical work performed during a plant-wide rolling outage.

The multi-product conversion project ran concurrently with the media expansion capability to existing validated production trains.  Hart was responsible for the coordination and installation of 20,000 liter buffer tanks and distribution, and (4) process vessels up to 7500 liters.  Additionally, Hart implemented modifications to chromatography and purification skids, and to all hygienic process and utility systems.  Hart also converted storage space to a process engineering lab, and performed all necessary cleaning and passivation of process systems.

These projects are a testament to the highly specialized capabilities of Hart’s team of project management and tradespeople.

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